The purpose of this research was to formulation, optimization and in vitro evaluation of floating bioadhesive tablets of 5-Fluorouracil (5-FU) anticancer drug. The main objective of the present study was to increase the gastric retention for prolonging the release of drug. A drug delivery system for anticancer drug 5-FU was developed utilizing both the concepts of Floatation and Bioadhesion, in order to obtain a unique drug delivery system which could remain in the stomach for a longer period of time. For the development of floating bioadhesive tablets used polymers like HPMC K15M and Carbopol 934P as a bioadhesive polymer with gas generating agents.. The formulation was optimized by 32 factorial design which was employed to study independent variable X1 (concentration of CP 934P) and X2 (concentration of HPMC K15M) and dependent variables as Y1 (floating lag time), Y2 (% swelling index at 10 hr) and Y3 (cumulative % drug release at 12 hr). The optimized batch showed the optimum floating lag time 26.67�±1.53 seconds, bioadhesive strength 21.96�±0.08 gm/cm2, % swelling index at 10 hr 74.78�±1.22 and cumulative % drug release at 12 hr 90.18�±0.17. Thus the floating bioadhesive tablets were successfully formulated to obtain gastric retention as well as controlled release of the drug.\r\nKey Words: 5 Fluorouracil, Gastric retention, HPMC K15M, Carbopol 934P etc.
Loading....